stimulant (nicotine) is taken after a depressant. In contrast, injection of marijuana's main active component THC increases the power of a meprobamate dose in animals. Meprobamate has been used in combination with dextroamphetamine for human weight loss, a combination that had uncertain effectiveness but that produced fewer unwanted actions than dextroamphetamine alone. Alcohol and meprobamate each have similar unwanted effects, and in that regard using both together can be the equivalent of taking extra doses of one or the other. Among steady drinkers, however, blood levels of meprobamate decline faster than in nondrinkers, meaning a meprobamate dose lasts a shorter time in the drinkers. A mice study indicated that poisonous effects of meprobamate worsen if either alcohol or phenobarbital is also used. Phenobarbital and other barbiturates have cross-tolerance with mepro-bamate, meaning that the barbiturates can substitute for meprobamate in at least some respects.
Cancer. Not enough scientific information to report.
Pregnancy. Meprobamate administered into chicken eggs results in embryo malformations, and skeletal deformity has been observed with fetal development in rats exposed to the compound. The drug passes into a human fetus. A study of over 50,000 pregnancies, including many women who used meprobamate, found no evidence of birth defects linked to the drug, findings duplicated by another analysis of outcomes in more than 6,000 pregnancies. Nonetheless, meprobamate is suspected of causing birth defects. Indeed, in a study of almost 20,000 pregnancies, birth defects were over twice as common among women using meprobamate during early pregnancy than among women who used other antianxiety drugs and more than four times as common compared to women who took no drug at all in early pregnancy. One study found that congenital heart lesions occurred more often if meprobamate was used during pregnancy. Rats with fetal exposure to meprobamate show learning difficulties, and tests of five-year-old children who had prenatal exposure to the substance reveal impaired reasoning ability. The meprobamate level in milk of nursing mothers has been measured as up to four times higher than the level in their blood.
Additional scientific information may be found in:
Carson, J. "Meprobamate Revisited." New York State Journal of Pharmacy 2 (1989): 45-46.
Gomolin, I. "Meprobamate." Clinical Toxicology 18 (1981): 757-60.
Greenblatt, D.J., and R.I. Shader. "Meprobamate: A Study of Irrational Drug Use."
American Journal of Psychiatry 127 (1971): 1297-1303. Logan, B.K., G.A. Case, and A.M. Gordon. "Carisoprodol, Meprobamate, and Driving
Impairment." Journal of Forensic Sciences 45 (2000): 619-23. McNair, D.M. "Antianxiety Drugs and Human Performance." Archives of General Psychiatry 29 (1973): 611-17. "Meprobamate." Medical Letter on Drugs and Therapeutics 7 (1965): 36.
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